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rink amide polystyrene resin  (Chem Impex International)
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valproic acid  (ZeptoMetrix corporation)
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Figure 4. Treatment <t>with</t> <t>antiepileptic</t> drugs at 250 M. Statistically significant decreases in locomotion (distance traveled) and duration in the center of the open field were observed after treatment of zebrafish larvae with 250 M diazepam (C, D) or clemizole (G, H), but not after treatment with <t>valproic</t> acid (A, B) or trazodone (E, F; N 18 per group). Data are plotted in 30-s time bins showing mean SEM (left), and the 5-min total for each all individuals, are plotted on the right. p 0.001.
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az phe  (Chem Impex International)
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Figure 4. Treatment <t>with</t> <t>antiepileptic</t> drugs at 250 M. Statistically significant decreases in locomotion (distance traveled) and duration in the center of the open field were observed after treatment of zebrafish larvae with 250 M diazepam (C, D) or clemizole (G, H), but not after treatment with <t>valproic</t> acid (A, B) or trazodone (E, F; N 18 per group). Data are plotted in 30-s time bins showing mean SEM (left), and the 5-min total for each all individuals, are plotted on the right. p 0.001.
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α ketoglutaric acid  (Chem Impex International)
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Figure 4. Treatment <t>with</t> <t>antiepileptic</t> drugs at 250 M. Statistically significant decreases in locomotion (distance traveled) and duration in the center of the open field were observed after treatment of zebrafish larvae with 250 M diazepam (C, D) or clemizole (G, H), but not after treatment with <t>valproic</t> acid (A, B) or trazodone (E, F; N 18 per group). Data are plotted in 30-s time bins showing mean SEM (left), and the 5-min total for each all individuals, are plotted on the right. p 0.001.
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Image Search Results


Figure 4. Treatment with antiepileptic drugs at 250 M. Statistically significant decreases in locomotion (distance traveled) and duration in the center of the open field were observed after treatment of zebrafish larvae with 250 M diazepam (C, D) or clemizole (G, H), but not after treatment with valproic acid (A, B) or trazodone (E, F; N 18 per group). Data are plotted in 30-s time bins showing mean SEM (left), and the 5-min total for each all individuals, are plotted on the right. p 0.001.

Journal: eneuro

Article Title: Behavioral Comorbidities and Drug Treatments in a Zebrafish scn1lab Model of Dravet Syndrome

doi: 10.1523/eneuro.0066-17.2017

Figure Lengend Snippet: Figure 4. Treatment with antiepileptic drugs at 250 M. Statistically significant decreases in locomotion (distance traveled) and duration in the center of the open field were observed after treatment of zebrafish larvae with 250 M diazepam (C, D) or clemizole (G, H), but not after treatment with valproic acid (A, B) or trazodone (E, F; N 18 per group). Data are plotted in 30-s time bins showing mean SEM (left), and the 5-min total for each all individuals, are plotted on the right. p 0.001.

Article Snippet: Valproic acid, a broad spectrum antiepileptic drug (Tomson et al., 2016) commonly used in DS (Chiron and Dulac, 2011), exerts protective effects in larval or adult zebrafish exposed to the chemoconvulsant pentylenetetrazole: (1) decreasing behavioral or electrographic seizure activity and (2) improv- ing deficits in learning of a passive avoidance response (Lee et al., 2010).

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